Purinergic signalling is involved in several physiological and pathophysiological processes. P2X7 receptor (P2X7R) is a calcium-permeable ion channel that is gaining interest as a potential therapeutic target for the treatment of different diseases including inflammation, pain, psychiatric disorders and cancer. P2X7R is ubiquitously expressed and sensitive to high ATP levels, usually found in tumor microenvironment. P2X7R regulates several cell functions, from migration to cell death, but its selective contribution to tumor progression remains controversial.
Purinergic P2X7 Receptor: A Cation Channel Sensitive to Tumor Microenvironment
Scarpellino, Giorgia;Genova, Tullio;Munaron, Luca
Last
2019-01-01
Abstract
Purinergic signalling is involved in several physiological and pathophysiological processes. P2X7 receptor (P2X7R) is a calcium-permeable ion channel that is gaining interest as a potential therapeutic target for the treatment of different diseases including inflammation, pain, psychiatric disorders and cancer. P2X7R is ubiquitously expressed and sensitive to high ATP levels, usually found in tumor microenvironment. P2X7R regulates several cell functions, from migration to cell death, but its selective contribution to tumor progression remains controversial.
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