The management of infection in Intensive Care Unit represents an imperative challenge for critical care clinicians. At present, antibiotic dosing regimens are derived from studies on healthy volunteers and do not account for these major differences in drug prescriptions. We summarized the pharmacokinetic/pharmacodynamics relationship changes in antimicrobial agents due to the typical homeostatic disturbance or altered end-organ function of the critical illness. We focused on how the renal clearance alterations or the Continuous Renal Replacement Therapy may affect individual antimicrobial dosage and dosing interval of the antimicrobial agents.

Antibiotic adjustment in CRRT

Fiorenza Ferrari;Paola Milla
2018

Abstract

The management of infection in Intensive Care Unit represents an imperative challenge for critical care clinicians. At present, antibiotic dosing regimens are derived from studies on healthy volunteers and do not account for these major differences in drug prescriptions. We summarized the pharmacokinetic/pharmacodynamics relationship changes in antimicrobial agents due to the typical homeostatic disturbance or altered end-organ function of the critical illness. We focused on how the renal clearance alterations or the Continuous Renal Replacement Therapy may affect individual antimicrobial dosage and dosing interval of the antimicrobial agents.
Critical Care Nephrology, 3rd Edition
Elsevier
1051
1067
978-0-323-44942-7
https://www.elsevier.ca/ca/product.jsp?isbn=9780323449427
Pharmacokinetic/Pharmacodynamic relationship, Adjustment antimicrobial dosage regimen, Critical illness, Acute renal failure, Extracorporeal blood purification therapy
Fiorenza Ferrari, Marco Sartori, Paola Milla
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1689735
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