During orthotopic liver transplantation (OLT), liver graft ischemia-reperfusion injury (IRI) triggers a cytokine-mediated systemic inflammatory response, which impairs graft function and disrupts distal organ homeostasis. The objective of this prospective, observational trial was to assess the effects of IRI on lung and chest wall mechanics in the intraoperative period of patients undergoing OLT.

Effects of liver ischemia-reperfusion injury on respiratory mechanics and driving pressure during orthotopic liver transplantation

Fanelli, Vito
First
;
CAROSSO, FABIO;Rotondo, Giuseppe;Pivetta, Emanuele E;Cappello, Paola;Mazzeo, Anna;Brazzi, Luca;Romagnoli, Renato;
2019

Abstract

During orthotopic liver transplantation (OLT), liver graft ischemia-reperfusion injury (IRI) triggers a cytokine-mediated systemic inflammatory response, which impairs graft function and disrupts distal organ homeostasis. The objective of this prospective, observational trial was to assess the effects of IRI on lung and chest wall mechanics in the intraoperative period of patients undergoing OLT.
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Fanelli, Vito; Costamagna, Andrea; Carosso, Fabio; Rotondo, Giuseppe; Pivetta, Emanuele E; Panio, Angelo; Cappello, Paola; Mazzeo, Anna; Del Sorbo, Lorenzo; Grasso, Salvatore; Mascia, Luciana; Brazzi, Luca; Romagnoli, Renato; Salizzoni, Mauro; Ranieri, Marco V
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1690113
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