Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroads between the immune system, clotting cascade, and endothelial cells, platelets seem to be an appealing central mediator and possible therapeutic target in sepsis. This review focuses on the pathogenic role of platelets in septic organ dysfunction in humans and animal models.

Platelets and multi-organ failure in sepsis

Greco, Elisabetta;Lupia, Enrico;Bosco, Ornella;Vizio, Barbara;Montrucchio, Giuseppe
Last
2017-01-01

Abstract

Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroads between the immune system, clotting cascade, and endothelial cells, platelets seem to be an appealing central mediator and possible therapeutic target in sepsis. This review focuses on the pathogenic role of platelets in septic organ dysfunction in humans and animal models.
2017
18
10
2200
2209
http://www.mdpi.com/1422-0067/18/10/2200/pdf
AKI; Antiplatelets; ARDS; DIC; Multi-organ failure; Platelet; Sepsis; Septic shock; Thrombocytopenia; Animals; Biomarkers; Blood Platelets; Humans; Multiple Organ Failure; Platelet Activation; Sepsis; Severity of Illness Index; Catalysis; Molecular Biology; Spectroscopy; Computer Science Applications1707 Computer Vision and Pattern Recognition; Physical and Theoretical Chemistry; Organic Chemistry; Inorganic Chemistry
Greco, Elisabetta; Lupia, Enrico; Bosco, Ornella; Vizio, Barbara; Montrucchio, Giuseppe*
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1693459
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