Irisin is a novel protein produced mainly by muscle, which is known to be released into the circulation, with an unclear role in liver fat deposition. This study demonstrates that genetic variants in the gene encoding the irisin protein modulate the risk of liver fat in patients with fatty liver disease. Interestingly, these effects are independent of, but additive to those of other recently described genetic variants that contribute to liver fat. In functional studies, we have deciphered the detailed molecular mechanisms by which this genetic variant mediates its effects.

A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3′UTR

Bugianesi, Elisabetta;
2019-01-01

Abstract

Irisin is a novel protein produced mainly by muscle, which is known to be released into the circulation, with an unclear role in liver fat deposition. This study demonstrates that genetic variants in the gene encoding the irisin protein modulate the risk of liver fat in patients with fatty liver disease. Interestingly, these effects are independent of, but additive to those of other recently described genetic variants that contribute to liver fat. In functional studies, we have deciphered the detailed molecular mechanisms by which this genetic variant mediates its effects.
2019
70
3
494
500
http://www.sciencedirect.com/science/journal/01688278
Fibrosis; Irisin; NAFLD; NASH; Steatosis; Hepatology
Metwally, Mayada; Bayoumi, Ali; Romero-Gomez, Manuel; Thabet, Khaled; John, Miya; Adams, Leon A.; Huo, Xiaoqi; Aller, Rocio; García-Monzón, Carmelo; Teresa Arias-Loste, María; Bugianesi, Elisabetta; Miele, Luca; Gallego-Durán, Rocio; Fischer, Janett; Berg, Thomas; Liddle, Christopher; Qiao, Liang; George, Jacob*; Eslam, Mohammed
File in questo prodotto:
File Dimensione Formato  
Metwally M_J Hepatol 2019.doc

Accesso riservato

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 3.81 MB
Formato Adobe PDF
3.81 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Metwally M_J Hepatol 2019.pdf

Open Access dal 01/11/2019

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 965.46 kB
Formato Adobe PDF
965.46 kB Adobe PDF Visualizza/Apri
1-s2.0-S0168827818325054-main.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 772.94 kB
Formato Adobe PDF
772.94 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1694128
Citazioni
  • ???jsp.display-item.citation.pmc??? 32
  • Scopus 64
  • ???jsp.display-item.citation.isi??? 64
social impact