Neuropsychiatric symptoms (NPs) have been reported with dolutegravir use. We hypothesized that increasing dolutegravir trough concentrations (Ctrough) and/or polymorphism in the SLC22A2 gene, encoding the organic cation transporter-2 (OCT2), which is involved in monoamine clearance in the CNS and is inhibited by dolutegravir, might be associated with NPs.
SLC22A2 variants and dolutegravir levels correlate with psychiatric symptoms in persons with HIV
Calcagno, A;Cusato, J;D'Avolio, A;Di Perri, G;Bonora, S;
2019-01-01
Abstract
Neuropsychiatric symptoms (NPs) have been reported with dolutegravir use. We hypothesized that increasing dolutegravir trough concentrations (Ctrough) and/or polymorphism in the SLC22A2 gene, encoding the organic cation transporter-2 (OCT2), which is involved in monoamine clearance in the CNS and is inhibited by dolutegravir, might be associated with NPs.
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OCT2 and DTG toxicity Borghetti JAC 2018.pdf
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SLC22A2 Genetic Varianiant dolutegravir manoscritto ADL.docx
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SLC22A2 Genetic Varianiant dolutegravir manoscritto ADL.pdf
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SLC22A2 Genetic Varianiant dolutegravir manoscritto ADL.pdf
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