Ticks and ear biopsies were collected from wild small rodents in 2011 and 2012 in the northern Apennines (Italy), up to 1650m above sea level. Apodemus spp. (n=83) and Myodes glareolus (n=22) were infested by Ixodes ricinus (192 larvae and two nymphs), Dermacentor marginatus (179 larvae and 29 nymphs), and Ixodes trianguliceps (three larvae and two nymphs). We detected several Borrelia burgdorferi sensu lato (s.l.) genospecies (B. afzelii, B. burgdorferi sensu stricto, B. garinii, B. lusitaniae, B. valaisiana) in I. ricinus and skin biopsies. The most common genospecies found in I. ricinus was B. valaisiana, while it was B. lusitaniae in tissues. Spotted fever group (SFG) rickettsiae (Rickettsia monacensis, R. slovaca and R. raoultii) infected I. ricinus, D. marginatus and rodent tissues. Rickettsia slovaca was the Rickettsia species most frequently found in our samples. Coinfections by B. burgdorferi s.l. and SFG rickettsiae indicate an overlap of transmission cycles and potential risk for humans to be infected by multiple pathogens, resulting in more severe symptoms. The findings of B. lusitaniae and R. slovaca in bank voles, and of B. valaisiana in small rodents, open new questions about host-pathogen interactions. In addition, our results highlight the importance of small rodents as data sources for studying tick-borne pathogens.

Borrelia burgdorferi sensu lato and spotted fever group rickettsiae in small rodents and attached ticks in the Northern Apennines, Italy

Martello, Elisa;Mannelli, Alessandro;Grego, Elena;Ceballos, Leonardo Adrian;Stella, Maria Cristina;Tomassone, Laura
2019

Abstract

Ticks and ear biopsies were collected from wild small rodents in 2011 and 2012 in the northern Apennines (Italy), up to 1650m above sea level. Apodemus spp. (n=83) and Myodes glareolus (n=22) were infested by Ixodes ricinus (192 larvae and two nymphs), Dermacentor marginatus (179 larvae and 29 nymphs), and Ixodes trianguliceps (three larvae and two nymphs). We detected several Borrelia burgdorferi sensu lato (s.l.) genospecies (B. afzelii, B. burgdorferi sensu stricto, B. garinii, B. lusitaniae, B. valaisiana) in I. ricinus and skin biopsies. The most common genospecies found in I. ricinus was B. valaisiana, while it was B. lusitaniae in tissues. Spotted fever group (SFG) rickettsiae (Rickettsia monacensis, R. slovaca and R. raoultii) infected I. ricinus, D. marginatus and rodent tissues. Rickettsia slovaca was the Rickettsia species most frequently found in our samples. Coinfections by B. burgdorferi s.l. and SFG rickettsiae indicate an overlap of transmission cycles and potential risk for humans to be infected by multiple pathogens, resulting in more severe symptoms. The findings of B. lusitaniae and R. slovaca in bank voles, and of B. valaisiana in small rodents, open new questions about host-pathogen interactions. In addition, our results highlight the importance of small rodents as data sources for studying tick-borne pathogens.
862
867
http://www.elsevier.com/wps/find/journaldescription.cws_home/721452/description#description
Borrelia burgdorferi s.l.; Spotted fever group rickettsiae; Rodents; Altitude; Coinfection; Italy
Martello, Elisa*; Mannelli, Alessandro; Grego, Elena; Ceballos, Leonardo Adrian; Ragagli, Charlotte; Stella, Maria Cristina; Tomassone, Laura
File in questo prodotto:
File Dimensione Formato  
Martello19_postprint_TTBD_final.docx

Accesso riservato

Descrizione: articolo post print
Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 161.94 kB
Formato Microsoft Word XML
161.94 kB Microsoft Word XML   Visualizza/Apri   Richiedi una copia
Martello_et_al_2019.pdf

Accesso riservato

Descrizione: versione dell'editore
Tipo di file: PDF EDITORIALE
Dimensione 423.92 kB
Formato Adobe PDF
423.92 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Martello19_postprint_TTBD_final.pdf

Accesso aperto con embargo fino al 14/04/2020

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 174.49 kB
Formato Adobe PDF
174.49 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1700196
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 14
social impact