Zika virus (ZIKV) is an emerging infectious viral pathogen associated with severe fetal cerebral anomalies and the paralytic Guillain-Barrè syndrome in adults. It was the cause of a recent global health crisis following its entrance into a naïve population in the Americas. Nowadays, no vaccine or specific antiviral against ZIKV is available. In this study, we identified three polyoxometalates (POMs), the Anderson-Evans type [TeW6O24]6- (TeW6), and the Keggin-type [TiW11CoO40]8-_ (TiW11Co), and [Ti2PW10O40]7- (Ti2PW10), that inhibit ZIKV infection with EC50s in the low micromolar range. Ti2PW10, the POM with the greatest selectivity index (SI), was selected and the step of ZIKV replicative cycle putatively inhibited was investigated by specific antiviral assays. We demonstrated that Ti2PW10 targets the entry process of ZIKV infection and it is able to significantly reduce ZIKV progeny production. These results suggest that the polyanion Ti2PW10 could be a good starting point to develop an effective therapeutic to treat ZIKV infection.

Anti-zika virus activity of polyoxometalates

Francese, Rachele;Civra, Andrea;Rittà, Massimo;Donalisio, Manuela;Argenziano, Monica;Cavalli, Roberta;Lembo, David
2019

Abstract

Zika virus (ZIKV) is an emerging infectious viral pathogen associated with severe fetal cerebral anomalies and the paralytic Guillain-Barrè syndrome in adults. It was the cause of a recent global health crisis following its entrance into a naïve population in the Americas. Nowadays, no vaccine or specific antiviral against ZIKV is available. In this study, we identified three polyoxometalates (POMs), the Anderson-Evans type [TeW6O24]6- (TeW6), and the Keggin-type [TiW11CoO40]8-_ (TiW11Co), and [Ti2PW10O40]7- (Ti2PW10), that inhibit ZIKV infection with EC50s in the low micromolar range. Ti2PW10, the POM with the greatest selectivity index (SI), was selected and the step of ZIKV replicative cycle putatively inhibited was investigated by specific antiviral assays. We demonstrated that Ti2PW10 targets the entry process of ZIKV infection and it is able to significantly reduce ZIKV progeny production. These results suggest that the polyanion Ti2PW10 could be a good starting point to develop an effective therapeutic to treat ZIKV infection.
ANTIVIRAL RESEARCH
163
29
33
www.elsevier.com/locate/antiviral
Antivirals; Entry inhibitor; Flavivirus; Polyoxometalates; Zika virus; Pharmacology; Virology
Francese, Rachele; Civra, Andrea; Rittà, Massimo; Donalisio, Manuela; Argenziano, Monica; Cavalli, Roberta; Mougharbel, Ali S.; Kortz, Ulrich; Lembo, David*
File in questo prodotto:
File Dimensione Formato  
post print Zika.pdf

embargo fino al 14/01/2020

Descrizione: Articolo principale
Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 1.96 MB
Formato Adobe PDF
1.96 MB Adobe PDF Visualizza/Apri
Anti-zika virus activity of polyoxometalates.pdf

non disponibili

Descrizione: Articolo principale
Tipo di file: PDF EDITORIALE
Dimensione 653.23 kB
Formato Adobe PDF
653.23 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1701118
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 13
social impact