Bisphenol A, Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents

Abstract: Objectives. The purpose of this study was to investigate bisphenol A (BPA) and its role in the induction of oxidative stress and confirm the same for tobacco smoke. Methods. A total of 223 young, healthy students (7–19 years old) were recruited in Chivasso, Italy. A spot of urine of each subject was analyzed to quantify BPA, cotinine, and 15F2t-isoprostane. Results. BPA showed a slight increase of concentration proportional with increasing age, even though the 11–14 years age group had slightly lower results, inducing a V-shape. The same trend was observed for 15F2t-isoprostane and cotinine. The result of piecewise linear robust regression shows a break point of the eect of BPA on 15F2t-isoprostane at 6 ng/mg CREA (p < 0.001). At higher levels, 15F2t-isoprostane shows an exponential increase by more than threefold for each one-log unit of BPA. An increase of oxidative stress due to BPA was observed, but only from 6 ng/mg of CREA up. Passive tobacco smoke is also able to induce an increase in oxidative stress. Conclusion. Prevention against BPA and passive tobacco smoke represents an important tool for promoting the highest health standard.