Several factors contribute to the high variability of linezolid plasma exposure in patients. Very recently, it has been suggested that linezolid could be an ABCB1 substrate. Therefore, the present clinical study was aimed at investigating whether ABCB1 polymorphisms could predict linezolid pharmacokinetics in 27 critically ill patients.
A Common mdr1 Gene Polymorphism is Associated with Changes in Linezolid Clearance
Allegra, SarahCo-first
;Cusato, Jessica;Fatiguso, Giovanna;Corcione, Silvia;D'Avolio, Antonio
Last
2018-01-01
Abstract
Several factors contribute to the high variability of linezolid plasma exposure in patients. Very recently, it has been suggested that linezolid could be an ABCB1 substrate. Therefore, the present clinical study was aimed at investigating whether ABCB1 polymorphisms could predict linezolid pharmacokinetics in 27 critically ill patients.
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