Directed ortho metalation (DoM) or nucleophilic acyl substitution (SNAc) can be efficiently programmed on the same aromatic carboxylic acid amide, in a choline chloride-based eutectic mixture, by simply switching the nature of the organolithium reagent. Telescoped, one-pot ortho-lithiation/Suzuki-Miyaura cross-couplings have also been demonstrated for the first time in DESs.

Directed: Ortho-metalation-nucleophilic acyl substitution strategies in deep eutectic solvents: The organolithium base dictates the chemoselectivity

GHINATO, SIMONE;Blangetti M.
;
Prandi C.
2019

Abstract

Directed ortho metalation (DoM) or nucleophilic acyl substitution (SNAc) can be efficiently programmed on the same aromatic carboxylic acid amide, in a choline chloride-based eutectic mixture, by simply switching the nature of the organolithium reagent. Telescoped, one-pot ortho-lithiation/Suzuki-Miyaura cross-couplings have also been demonstrated for the first time in DESs.
55
54
7741
7744
http://pubs.rsc.org/en/journals/journal/cc
DES, organolithium, DoM
Ghinato S.; Dilauro G.; Perna F.M.; Capriati V.; Blangetti M.; Prandi C.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1707022
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