The timing of puberty is highly sensitive to environmental factors, including endocrine disruptors. Among them, bisphenol A (BPA) has been previously analyzed as potential modifier of puberty. Yet, disparate results have been reported, with BPA advancing, delaying, or being neutral in its effects on puberty onset. Likewise, mechanistic analyses addressing the central and peripheral actions/targets of BPA at puberty remain incomplete and conflictive.

Environmentally Relevant Perinatal Exposures to Bisphenol A Disrupt Postnatal Kiss1/NKB Neuronal Maturation and Puberty Onset in Female Mice

Miceli, Desiree;Farinetti, Alice;Panzica, GianCarlo;
2019

Abstract

The timing of puberty is highly sensitive to environmental factors, including endocrine disruptors. Among them, bisphenol A (BPA) has been previously analyzed as potential modifier of puberty. Yet, disparate results have been reported, with BPA advancing, delaying, or being neutral in its effects on puberty onset. Likewise, mechanistic analyses addressing the central and peripheral actions/targets of BPA at puberty remain incomplete and conflictive.
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https://ehp.niehs.nih.gov/doi/full/10.1289/EHP5570
kisspeptin, development, bisphemol A, BPA, female, mouse, puberty onset, endocrine disruptors
Ruiz-Pino, Francisco; Miceli, Desiree; Franssen, Delphine; Vazquez, Maria Jesus; Farinetti, Alice; Castellano, Juan Manuel; Panzica, GianCarlo; Tena-Sempere, Manuel
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1714930
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