LC-MS/MS based quantification of nine antiepileptic drugs from dried sample spots device

Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is commonly performed on plasma or serum. The use of Dried Plasma Spots (DPS) could represent a useful tool to facilitate sample shipment to reference laboratories. In this paper, the authors describe the application of a commercially available UHPLC-MS/MS method for the determination of nine commonly prescribed AEDs (levetiracetam, lacosamide, topiramate, ethosuximide, lamotrigine, rufinamide, zonisamide, primidone, oxcarbazepine and its active metabolite 10-OH-monohydroxycarbazepine) to DPS collected on Dried Sample Spot Devices (DSSD).