Human CD157/BST-1 and CD38 are dual receptor-enzymes derived by gene duplication that belong to the ADP ribosyl cyclase gene family. First identified over 30 years ago as Mo5 myeloid differentiation antigen and 10 years later as Bone Marrow Stromal Cell Antigen 1 (BST-1), CD157 proved not to be restricted to the myeloid compartment and to have a diversified functional repertoire ranging from immunity to cancer and metabolism. Despite being a NAD+-metabolizing ectoenzyme anchored to the cell surface through a glycosylphosphatidylinositol moiety, the functional significance of human CD157 as an enzyme remains unclear, while its receptor role emerged from its discovery and has been clearly delineated with the identification of its high affinity binding to fibronectin. The aim of this review is to provide an overview of the immunoregulatory functions of human CD157/BST-1 in physiological and pathological conditions. We then focus on CD157 expression in hematological tumors highlighting its emerging role in the interaction between acute myeloid

CD157: From Myeloid Cell Differentiation Marker to Therapeutic Target in Acute Myeloid Leukemia.

Yuliya Yakymiv;Stefania Augeri;Giulia Fissolo;Silvia Peola;Cristiano Bracci;Enza Ferrero;Erika Ortolan;Ada Funaro
Last
2019

Abstract

Human CD157/BST-1 and CD38 are dual receptor-enzymes derived by gene duplication that belong to the ADP ribosyl cyclase gene family. First identified over 30 years ago as Mo5 myeloid differentiation antigen and 10 years later as Bone Marrow Stromal Cell Antigen 1 (BST-1), CD157 proved not to be restricted to the myeloid compartment and to have a diversified functional repertoire ranging from immunity to cancer and metabolism. Despite being a NAD+-metabolizing ectoenzyme anchored to the cell surface through a glycosylphosphatidylinositol moiety, the functional significance of human CD157 as an enzyme remains unclear, while its receptor role emerged from its discovery and has been clearly delineated with the identification of its high affinity binding to fibronectin. The aim of this review is to provide an overview of the immunoregulatory functions of human CD157/BST-1 in physiological and pathological conditions. We then focus on CD157 expression in hematological tumors highlighting its emerging role in the interaction between acute myeloid
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https://www.mdpi.com/2073-4409/8/12/1580
CD157/BST-1; MEN1112/OBT357; acute myeloid leukemia; cell adhesion; cyclic ADPR; myeloid cells; stem cells; therapeutic defucosylated monoclonal antibody
Yuliya Yakymiv, Stefania Augeri, Giulia Fissolo, Silvia Peola, Cristiano Bracci, Monica Binaschi, Daniela Bellarosa, Andrea Pellacani, Enza Ferrero, Erika Ortolan, Ada Funaro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1719287
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