Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer.Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug.Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy cell line, while being toxic against cancer cells. Haemolysis test was performed to evaluate the blood-compatibility characteristic of nanosponge and complex and the results showed 0.54% haemolysis in the lowest complex concentration (50μgml-1) and 5.09% at the highest concentration (200μgml-1).Conclusions: Thus, the introduced system could be widely considered in cancer treatment as a drug delivery system.

Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations

Caldera F.;Trotta F.;
2019

Abstract

Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer.Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug.Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy cell line, while being toxic against cancer cells. Haemolysis test was performed to evaluate the blood-compatibility characteristic of nanosponge and complex and the results showed 0.54% haemolysis in the lowest complex concentration (50μgml-1) and 5.09% at the highest concentration (200μgml-1).Conclusions: Thus, the introduced system could be widely considered in cancer treatment as a drug delivery system.
JOURNAL OF MICROENCAPSULATION
36
8
715
727
http://www.tandfonline.com/loi/imnc20
anti-cancer, curcumin, inclusion complex, Nanosponge, solubility
Rafati N.; Zarrabi A.; Caldera F.; Trotta F.; Ghias N.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1721037
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