In this issue, Grange et al. (2019) show the therapeutic activity of urine-derived EVs in a murine model of acute kidney injury and highlight the presence and indispensable role of the reno-protective factor Klotho carried by uEVs. The regenerative capacity of EVs engineered with human recombinant Klotho is also proposed.

Urinary Extracellular Vesicles Carrying Klotho Improve the Recovery of Renal Function in an Acute Tubular Injury Model

Grange C.;Papadimitriou E.;Dimuccio V.;Pastorino C.;Molina J.;Camussi G.;Bussolati B.
Last
2020-01-01

Abstract

In this issue, Grange et al. (2019) show the therapeutic activity of urine-derived EVs in a murine model of acute kidney injury and highlight the presence and indispensable role of the reno-protective factor Klotho carried by uEVs. The regenerative capacity of EVs engineered with human recombinant Klotho is also proposed.
2020
28
2
490
502
https://www.journals.elsevier.com/molecular-therapy
AKI; damage; engineering; injury markers; Klotho; mesenchymal stem cells; microRNAs; renal regeneration; urinary exosomes; vesicles
Grange C.; Papadimitriou E.; Dimuccio V.; Pastorino C.; Molina J.; O'Kelly R.; Niedernhofer L.J.; Robbins P.D.; Camussi G.; Bussolati B.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1726934
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