Defects in the homologous recombination (HR) repair pathway are of clinical interest due to sensitivity of HR-deficient cells to PARP inhibitors. We were interested in defining PARP vulnerability in patients with metastatic colorectal cancer (mCRC) carrying KRAS and BRAF mutations who display poor prognosis, have limited therapeutic options, and represent an unmet clinical need.

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

Arena, Sabrina
First
;
Corti, Giorgio;Russo, Mariangela;Lorenzato, Annalisa;Arcella, Pamela;Rospo, Giuseppe;Pagani, Massimiliano;Negrino, Carola;Isella, Claudio;Mittica, Gloria;Medico, Enzo;Di Nicolantonio, Federica;Bardelli, Alberto
Last
2019

Abstract

Defects in the homologous recombination (HR) repair pathway are of clinical interest due to sensitivity of HR-deficient cells to PARP inhibitors. We were interested in defining PARP vulnerability in patients with metastatic colorectal cancer (mCRC) carrying KRAS and BRAF mutations who display poor prognosis, have limited therapeutic options, and represent an unmet clinical need.
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14
Arena, Sabrina; Corti, Giorgio; Durinikova, Erika; Montone, Monica; Reilly, Nicole M; Russo, Mariangela; Lorenzato, Annalisa; Arcella, Pamela; Lazzari, Luca; Rospo, Giuseppe; Pagani, Massimiliano; Cancelliere, Carlotta; Negrino, Carola; Isella, Claudio; Bartolini, Alice; Cassingena, Andrea; Amatu, Alessio; Mauri, Gianluca; Sartore-Bianchi, Andrea; Mittica, Gloria; Medico, Enzo; Marsoni, Silvia; Linnebacher, Michael; Abrignani, Sergio; Siena, Salvatore; Di Nicolantonio, Federica; Bardelli, Alberto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1728652
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