This review summarises the recent progress made in the organocatalytic synthesis of atropisomeric compounds. Methodologies based on dynamic kinetic resolution and direct access to BINOL-like biaryls are described. A particular emphasis is given to reaction mechanisms and to the development of strategies to obtain stable products by increasing the barrier to atropisomer interconversion during the reaction.
Organocatalytic synthesis of axially chiral atropisomers
Renzi, P.
2017-01-01
Abstract
This review summarises the recent progress made in the organocatalytic synthesis of atropisomeric compounds. Methodologies based on dynamic kinetic resolution and direct access to BINOL-like biaryls are described. A particular emphasis is given to reaction mechanisms and to the development of strategies to obtain stable products by increasing the barrier to atropisomer interconversion during the reaction.
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