Apoptosis plays a crucial role in clearing old or critically compromised cells, and actively maintains epithelial homeostasis and epithelial morphogenesis during embryo development. But how is the apoptotic signaling pathway able to orchestrate such complex and dynamic multi-cellular morphological events at the tissue scale? In this review we collected the most updated knowledge regarding how apoptosis controls different cytoskeletal components. We describe how apoptosis can control epithelial homeostasis though epithelial extrusion, a highly orchestrated process based on high- order actomyosin structures and on the coordination between the apoptotic and the neighboring cells. Finally, we describe how the synergy among forces generated by multiple apoptotic cells can shape epithelia in embryo development.

Death for life: a path from apoptotic signaling to tissue-scale effects of apoptotic epithelial extrusion

Gagliardi P. A.;Primo L.
Last
2019

Abstract

Apoptosis plays a crucial role in clearing old or critically compromised cells, and actively maintains epithelial homeostasis and epithelial morphogenesis during embryo development. But how is the apoptotic signaling pathway able to orchestrate such complex and dynamic multi-cellular morphological events at the tissue scale? In this review we collected the most updated knowledge regarding how apoptosis controls different cytoskeletal components. We describe how apoptosis can control epithelial homeostasis though epithelial extrusion, a highly orchestrated process based on high- order actomyosin structures and on the coordination between the apoptotic and the neighboring cells. Finally, we describe how the synergy among forces generated by multiple apoptotic cells can shape epithelia in embryo development.
76
18
3571
3581
http://link.springer.de/link/service/journals/00018/index.htm
Actomyosin cytoskeleton; Apoptosis; Caspase; Epithelial extrusion; MRCK; ROCK; Animals; Cytoskeleton; Embryonic Development; Epithelial Cells; Homeostasis; Myotonin-Protein Kinase; Signal Transduction; rho-Associated Kinases; Apoptosis
Gagliardi P.A.; Primo L.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1729728
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