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EnglishMethimazole (MMI) is often the selected medical treatment for feline hyperthyroidism. However, the onset of MMI-related side effects (MMI-SE) is likely caused by oxidative stress. This study evaluated the dietary supplementation of selected antioxidants in hyperthyroid cats receiving MMI, to reduce MMI-SE. Thirty hyperthyroid client-owned cats were randomly allocated in group M (MMI + placebo) or group M+A (MMI + antioxidants). At different time-points from the enrolment (ET) to the end of the trial (FT), the following information was recorded: clinical findings, complete blood count, serum biochemical parameters, urinalysis, total plasma thyroxine concentrations, determinable reactive oxygen metabolites (dROMs), OXY-adsorbent test, and oxidative stress index (OSi) values, and MMI-SE. dROMs and OSi values significantly increased from ET to FT in group M and were significantly higher in group M than in group M+A at FT. Likewise, OXY-absorbent values were significantly higher in group M+A than in group M at FT. Moreover, the occurrence rate of MMI-SE in group M+A was lower than in group M. In conclusion, our results show that the dietary supplementation of antioxidants in hyperthyroid cats receiving MMI exerts a protective effect against oxidative stress, likely contributing to the reduction of MMISE.
| Titolo: | Evaluation of antioxidant supplementation on redox unbalance in hyperthyroid cats treated with methimazole: A blinded randomized controlled trial | |
| Autori Riconosciuti: | ||
| Autori: | Candellone A.; Badino P.; Gianella P.; Girolami F.; Raviri G.; Saettone V.; Meineri G. | |
| Data di pubblicazione: | 2020 | |
| Abstract: | Methimazole (MMI) is often the selected medical treatment for feline hyperthyroidism. However, the onset of MMI-related side effects (MMI-SE) is likely caused by oxidative stress. This study evaluated the dietary supplementation of selected antioxidants in hyperthyroid cats receiving MMI, to reduce MMI-SE. Thirty hyperthyroid client-owned cats were randomly allocated in group M (MMI + placebo) or group M+A (MMI + antioxidants). At different time-points from the enrolment (ET) to the end of the trial (FT), the following information was recorded: clinical findings, complete blood count, serum biochemical parameters, urinalysis, total plasma thyroxine concentrations, determinable reactive oxygen metabolites (dROMs), OXY-adsorbent test, and oxidative stress index (OSi) values, and MMI-SE. dROMs and OSi values significantly increased from ET to FT in group M and were significantly higher in group M than in group M+A at FT. Likewise, OXY-absorbent values were significantly higher in group M+A than in group M at FT. Moreover, the occurrence rate of MMI-SE in group M+A was lower than in group M. In conclusion, our results show that the dietary supplementation of antioxidants in hyperthyroid cats receiving MMI exerts a protective effect against oxidative stress, likely contributing to the reduction of MMISE. | |
| Volume: | 9 | |
| Fascicolo: | 1 | |
| Pagina iniziale: | 15 | |
| Pagina finale: | 15 | |
| Digital Object Identifier (DOI): | 10.3390/antiox9010015 | |
| URL: | https://www.mdpi.com/2076-3921/9/1/15/pdf | |
| Parole Chiave: | Antioxidants; Curcumin; Feline hyperthyroidism; Methimazole; Quercetin; Redox unbalance; Resveratrol; Vitamin E | |
| Rivista: | ANTIOXIDANTS | |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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| 22_Candellone_Antioxidants_2020.pdf | Articolo principale | PDF EDITORIALE | Open Access Visualizza/Apri |
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