Acton et al. identify the excitatory neurons in the dorsal spinal cord that drive mechanical itch. These cells mediate responses to light punctate touch and are inhibited by neuropeptide Y (NPY)::Cre interneurons. Light touch sensitivity and mechanical itch responses are gated by NPY signaling mediated by Y1-expressing neurons in the dorsal horn.

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch

Bertocchi I.;Eva C.;
2019-01-01

Abstract

Acton et al. identify the excitatory neurons in the dorsal spinal cord that drive mechanical itch. These cells mediate responses to light punctate touch and are inhibited by neuropeptide Y (NPY)::Cre interneurons. Light touch sensitivity and mechanical itch responses are gated by NPY signaling mediated by Y1-expressing neurons in the dorsal horn.
2019
Inglese
Esperti anonimi
28
3
625
639.e6
14
http://www.sciencedirect.com/science/journal/22111247
chemical itch; dorsal spinal cord; inhibition; mechanical itch transmission; neuropeptide Y; NPY1R signaling; pain; somatosensory processing; touch; Y1 excitatory neurons
STATI UNITI D'AMERICA
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8
Acton D.; Ren X.; Di Costanzo S.; Dalet A.; Bourane S.; Bertocchi I.; Eva C.; Goulding M.
info:eu-repo/semantics/article
open
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1731482
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