The heteroatom-directed lateral lithiation of functionalized toluenes in a choline chloride-based eutectic mixture is reported. The metalations proceed within ultrafast reaction times, with a broad substrate and electrophile scope. The directing groups provide a rapid and high regioselective access to functionalized aromatic derivatives of remarkable synthetic value.
Lateral lithiation in deep eutectic solvents: regioselective functionalization of substituted toluene derivatives
Arnodo, DavideCo-first
;Ghinato, SimoneCo-first
;Nejrotti, StefanoCo-first
;Blangetti, Marco
;Prandi, Cristina
2020-01-01
Abstract
The heteroatom-directed lateral lithiation of functionalized toluenes in a choline chloride-based eutectic mixture is reported. The metalations proceed within ultrafast reaction times, with a broad substrate and electrophile scope. The directing groups provide a rapid and high regioselective access to functionalized aromatic derivatives of remarkable synthetic value.
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