The heteroatom-directed lateral lithiation of functionalized toluenes in a choline chloride-based eutectic mixture is reported. The metalations proceed within ultrafast reaction times, with a broad substrate and electrophile scope. The directing groups provide a rapid and high regioselective access to functionalized aromatic derivatives of remarkable synthetic value.

Lateral lithiation in deep eutectic solvents: regioselective functionalization of substituted toluene derivatives

Arnodo, Davide;Ghinato, Simone;Nejrotti, Stefano;Blangetti, Marco;Prandi, Cristina
2020

Abstract

The heteroatom-directed lateral lithiation of functionalized toluenes in a choline chloride-based eutectic mixture is reported. The metalations proceed within ultrafast reaction times, with a broad substrate and electrophile scope. The directing groups provide a rapid and high regioselective access to functionalized aromatic derivatives of remarkable synthetic value.
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https://pubs.rsc.org/en/content/articlelanding/2020/cc/d0cc00593b#!divAbstract
Arnodo, Davide; Ghinato, Simone; Nejrotti, Stefano; Blangetti, Marco; Prandi, Cristina
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1732454
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