OBJECTIVES. The aim of this pilot observational study was to describe the clinical produttoefficacy of a hyper-oxidized oil based gel, with film-forming and protective function, in patients affected by traumatic physical oral ulcers. MATERIALS AND METHODS. The material under evaluation was a hyperoxidized oil based gel (Novox®, Moss SpA, Lesa, Novara, Italy), packaged in appropriate syringes by the producer. The medication was applied 3 times daily for 1 week. Twenty-one patients were recruited. All subjects were carefully instructed about how to use it: finger rub application on dried lesions after meals, without eating, drinking or speaking for at least half an hour afterwards. Outcome measures evaluated were pain perception and lesion dimension, assessed before and after the proposed therapy. RESULTS AND CONCLUSIONS. After the delivered treatment, a statistically significant reduction was observed in pain (p = 0.000) and lesion size (p = 0.000). The results of this pilot study suggest that the application of a hyper- oxidized oil may represent a novel and effective treatment for accelerating the healing process and for pain reduction in traumatic oral mucosal lesions. However, more comprehensive and randomized controlled studies will be necessary to confirm our preliminary findings.
Treatment efficacy of a hyper-oxidized oil in oral traumatic ulcers: A pilot study.
Arduino P. G.
First
;Cabras M.;Broccoletti R.
Last
2016-01-01
Abstract
OBJECTIVES. The aim of this pilot observational study was to describe the clinical produttoefficacy of a hyper-oxidized oil based gel, with film-forming and protective function, in patients affected by traumatic physical oral ulcers. MATERIALS AND METHODS. The material under evaluation was a hyperoxidized oil based gel (Novox®, Moss SpA, Lesa, Novara, Italy), packaged in appropriate syringes by the producer. The medication was applied 3 times daily for 1 week. Twenty-one patients were recruited. All subjects were carefully instructed about how to use it: finger rub application on dried lesions after meals, without eating, drinking or speaking for at least half an hour afterwards. Outcome measures evaluated were pain perception and lesion dimension, assessed before and after the proposed therapy. RESULTS AND CONCLUSIONS. After the delivered treatment, a statistically significant reduction was observed in pain (p = 0.000) and lesion size (p = 0.000). The results of this pilot study suggest that the application of a hyper- oxidized oil may represent a novel and effective treatment for accelerating the healing process and for pain reduction in traumatic oral mucosal lesions. However, more comprehensive and randomized controlled studies will be necessary to confirm our preliminary findings.
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