Immunoglobulin-A vasculitis (IgAV) is a systemic small-vessel vasculitis in which renal involvement indicates severity of illness, and chronic kidney disease represents the most serious long-term complication. No treatment at present is specifically recommended for IgAV. Recently, rituximab (RTX) has been shown to be effective in case series of adults with IgAV. However, long term results are lacking. Aim of the study is to evaluate the effectiveness of RTX as induction therapy and maintenance of remission in adults with severe IgAV and aggressive glomerulonephritis.

Rituximab in severe immunoglobulin-A vasculitis (Henoch-Schönlein) with aggressive nephritis

Fenoglio, Roberta
First
;
Sciascia, Savino;Naretto, Carla;Del Vecchio, Giulio;Roccatello, Dario
Last
2020

Abstract

Immunoglobulin-A vasculitis (IgAV) is a systemic small-vessel vasculitis in which renal involvement indicates severity of illness, and chronic kidney disease represents the most serious long-term complication. No treatment at present is specifically recommended for IgAV. Recently, rituximab (RTX) has been shown to be effective in case series of adults with IgAV. However, long term results are lacking. Aim of the study is to evaluate the effectiveness of RTX as induction therapy and maintenance of remission in adults with severe IgAV and aggressive glomerulonephritis.
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Fenoglio, Roberta; Sciascia, Savino; Naretto, Carla; De Simone, Emanuele; Del Vecchio, Giulio; Ferro, Michela; Quattrocchio, Giacomo; Roccatello, Dario
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1740479
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