Cognitive Neuro-Rehabilitation of HIV-Associated Neurocognitive Disorders: Case Reports of A New Computer-Based Restorative Approach In 3 Hiv-Positive Cart-Treated Patients

At enrolment (T0) three on combination antiretroviral therapy (cART) HIV-positive patients with HIV Associated Neurocognitive Disorders (HAND) were enrolled to undergo a computer-based rehabilitation program (https://dynamicbrain.brainhq.com/) for 12 weeks, under the supervision of a physician. At the end (T1), the patients were tested again with a neuropsychological battery. Patient 1 (current CD4 T-cell count 405/mmc, HIV-RNA < 40UI/ml) had a diagnosis of mild neurocognitive disorders (MND) at T0 and normal evaluation at T1. Patient 2 (current CD4 T-cell count 366/mmc, HIV-RNA < 40UI/ml) had asymptomatic neurocognitive disorders (ANI) at T0 and normal performance at T1. Patient 3 (current CD4 T-cell count 522/mmc, HIV-RNA < 40UI/ml) had MND at T0 and normal performances at T1. Patients’ adherence to the program was 100%. Our pilot experience with a computer-based restorative approach showed good results in term of improvement in neuropsychological performances in treated HIV+ patients. These data suggest the need to explore innovative ways to manage HAND.