The multifactorial pathogenesis of HIV-Associated neurocognitive disorders may explain the inconsistent association between neurocognitive impairment and cerebrospinal fluid (CSF) HIV RNA. Clinical and VIRO-immunological (CSF and plasma HIV RNA, CSF/plasma HIV RNA ratio, circulating T-cell phenotypes) parameters were investigated in 155 HIV-infected, antiretroviral-naïve, asymptomatic study participants undergoing a neuropsychological evaluation. HIV associated neurocognitive disorders (HAND) was independently associated with AIDS events and a CSF/ plasma ratio of at least one, after adjustment for CD4R nadir of less than 200 cells/mmc, suggesting a role for active central nervous system (CNS) viral replication in the pathogenesis of neurocognitive impairment.

Clinical and VIRO-immunological correlates of HIV associated neurocognitive disorders (HAND) in a cohort of antiretroviral-naïve HIV-infected patients

Trunfio M.;
2017

Abstract

The multifactorial pathogenesis of HIV-Associated neurocognitive disorders may explain the inconsistent association between neurocognitive impairment and cerebrospinal fluid (CSF) HIV RNA. Clinical and VIRO-immunological (CSF and plasma HIV RNA, CSF/plasma HIV RNA ratio, circulating T-cell phenotypes) parameters were investigated in 155 HIV-infected, antiretroviral-naïve, asymptomatic study participants undergoing a neuropsychological evaluation. HIV associated neurocognitive disorders (HAND) was independently associated with AIDS events and a CSF/ plasma ratio of at least one, after adjustment for CD4R nadir of less than 200 cells/mmc, suggesting a role for active central nervous system (CNS) viral replication in the pathogenesis of neurocognitive impairment.
AIDS
31
2
311
314
AIDS Dementia Complex; Adult; Biomarkers; Cerebrospinal Fluid; Cohort Studies; Female; HIV Infections; Humans; Immunophenotyping; Male; Middle Aged; Plasma; RNA, Viral; T-Lymphocyte Subsets; Viral Load
Bai F.; Iannuzzia F.; Merlini E.; Borghi L.; Tincati C.; Trunfio M.; Bini T.; Monforte A.D.; Marchetti G.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1741985
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