Objective response rate to mitotane in advanced adrenocortical carcinoma (ACC) is approximately 20%, and adverse drug effects are frequent. To date, there is no marker established that predicts treatment response. Mitotane has been shown to inhibit sterol-O-acyl transferase 1 (SOAT1), which leads to endoplasmic reticulum stress and cell death in ACC cells.

Expression of SOAT1 in Adrenocortical Carcinoma and Response to Mitotane Monotherapy: An ENSAT Multicenter Study

Basile, Vittoria;Volante, Marco;Terzolo, Massimo;
2020-01-01

Abstract

Objective response rate to mitotane in advanced adrenocortical carcinoma (ACC) is approximately 20%, and adverse drug effects are frequent. To date, there is no marker established that predicts treatment response. Mitotane has been shown to inhibit sterol-O-acyl transferase 1 (SOAT1), which leads to endoplasmic reticulum stress and cell death in ACC cells.
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https://pubmed.ncbi.nlm.nih.gov/32449514/
adrenal cancer; chemotherapy; prognosis; treatment
Weigand, Isabel; Altieri, Barbara; Lacombe, Amanda M F; Basile, Vittoria; Kircher, Stefan; Landwehr, Laura-Sophie; Schreiner, Jochen; Zerbini, Maria C N; Ronchi, Cristina L; Megerle, Felix; Berruti, Alfredo; Canu, Letizia; Volante, Marco; Paiva, Isabel; Della Casa, Silvia; Sbiera, Silviu; Fassnacht, Martin; Fragoso, Maria Candida B V; Terzolo, Massimo; Kroiss, Matthias
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1742705
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