Congenitally- or perinatally-acquired viral infections can be harmful to the fetus but data are limited about prevalence and outcomes of COVID-19 disease during the first trimester of pregnancy. We report epidemiologic data from a study investigating a cohort of women who became pregnant just before or during the COVID-19 pandemic. We recruited 138 consecutive pregnant women attending for first trimester screening (11-13 weeks of gestation) at Sant'Anna Hospital, Turin, Piedmont, Italy, during the plateau and the falling phase of the COVID-19 epidemic curve. Patients were tested for SARS-CoV-2 IgM/IgG antibody levels and SARS-CoV-2 detection in sera and nasopharyngeal swab samples. COVID-19 cumulative incidence during the first trimester was of 10.1% with high prevalence of asymptomatic patients (42.8%). Similar to the course of the disease in non pregnant adults, 80-90% of infections were not severe. The prevalence of reported symptoms was four-fold higher in SARS-CoV-2 positive patients (57%) than in those negative (13%) (p<0.001), suggesting that direct self-testing should open doors to confirmatory testing for COVID-19. Our findings support the need for COVID-19 screening in early pregnancy in epidemic areas to plan materno-fetal health surveillance programs. This article is protected by copyright. All rights reserved.

The "scar" of a pandemic: cumulative incidence of COVID-19 during the first trimester of pregnancy

Cosma, Stefano
First
;
Borella, Fulvio;Carosso, Andrea;Cusato, Jessica;Corcione, Silvia;Mengozzi, Giulio;Preti, Mario;Katsaros, Dionyssios;Di Perri, Giovanni;Benedetto, Chiara
Last
2021

Abstract

Congenitally- or perinatally-acquired viral infections can be harmful to the fetus but data are limited about prevalence and outcomes of COVID-19 disease during the first trimester of pregnancy. We report epidemiologic data from a study investigating a cohort of women who became pregnant just before or during the COVID-19 pandemic. We recruited 138 consecutive pregnant women attending for first trimester screening (11-13 weeks of gestation) at Sant'Anna Hospital, Turin, Piedmont, Italy, during the plateau and the falling phase of the COVID-19 epidemic curve. Patients were tested for SARS-CoV-2 IgM/IgG antibody levels and SARS-CoV-2 detection in sera and nasopharyngeal swab samples. COVID-19 cumulative incidence during the first trimester was of 10.1% with high prevalence of asymptomatic patients (42.8%). Similar to the course of the disease in non pregnant adults, 80-90% of infections were not severe. The prevalence of reported symptoms was four-fold higher in SARS-CoV-2 positive patients (57%) than in those negative (13%) (p<0.001), suggesting that direct self-testing should open doors to confirmatory testing for COVID-19. Our findings support the need for COVID-19 screening in early pregnancy in epidemic areas to plan materno-fetal health surveillance programs. This article is protected by copyright. All rights reserved.
93
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537
540
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.26267
COVID-19; SARS-CoV-2; first trimester; pregnancy; seroprevalence
Cosma, Stefano; Borella, Fulvio; Carosso, Andrea; Sciarrone, Andrea; Cusato, Jessica; Corcione, Silvia; Mengozzi, Giulio; Preti, Mario; Katsaros, Dionyssios; Di Perri, Giovanni; Benedetto, Chiara
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1744502
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