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The role of m6A in the biogenesis and function of circRNAs has yet to be addressed. We discovered that METTL3 and YTHDC1 modulate the biogenesis of a subset of circRNAs, including circ-ZNF609. We show that m6A regulates circZNF609 translation via YTHDF3 and eIF4G2.

Modulation of circRNA Metabolism by m6A Modification

Oliviero S.;Bozzoni I.
Last
2020-01-01

Abstract

The role of m6A in the biogenesis and function of circRNAs has yet to be addressed. We discovered that METTL3 and YTHDC1 modulate the biogenesis of a subset of circRNAs, including circ-ZNF609. We show that m6A regulates circZNF609 translation via YTHDF3 and eIF4G2.
2020
CELL REPORTS
31
6
107641
107656
https://pubmed.ncbi.nlm.nih.gov/32402287/
back-splicing; cap-independent translation; circRNA; circRNA biogenesis; circRNA translation; epitrascriptome; m; 6; A modification; METTL3; YTHDC1
Di Timoteo G.; Dattilo D.; Centron-Broco A.; Colantoni A.; Guarnacci M.; Rossi F.; Incarnato D.; Oliviero S.; Fatica A.; Morlando M.; Bozzoni I....espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1747524
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