An unexpected drug-drug interaction has been recently reported between dolutegravir, an HIV integrase inhibitor, and valproic acid. Despite there being several potential underlying mechanisms, plasma protein displacement has been suggested. The aim of this study was to assess plasma concentrations of several antiretrovirals when administered with or without valproic acid.
Antiretroviral concentrations in the presence and absence of valproic acid
Calcagno, A
First
;Cusato, J;Ferrara, M;De Nicolò, A;Lazzaro, A;Manca, A;D'Avolio, A;Di Perri, G;Bonora, SLast
2020-01-01
Abstract
An unexpected drug-drug interaction has been recently reported between dolutegravir, an HIV integrase inhibitor, and valproic acid. Despite there being several potential underlying mechanisms, plasma protein displacement has been suggested. The aim of this study was to assess plasma concentrations of several antiretrovirals when administered with or without valproic acid.
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