Background: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.

Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Torelli N.;Serraino D.;Canova C.;Richiardi L.;Thomson P.;Li G.;Smith E.;Chen C.;Zheng T.;Boffetta P.;
2020

Abstract

Background: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.
Epub ahead of print
1
8
Di Credico G.; Polesel J.; Dal Maso L.; Pauli F.; Torelli N.; Luce D.; Radoi L.; Matsuo K.; Serraino D.; Brennan P.; Holcatova I.; Ahrens W.; Lagiou P.; Canova C.; Richiardi L.; Healy C.M.; Kjaerheim K.; Conway D.I.; Macfarlane G.J.; Thomson P.; Agudo A.; Znaor A.; Franceschi S.; Herrero R.; Toporcov T.N.; Moyses R.A.; Muscat J.; Negri E.; Vilensky M.; Fernandez L.; Curado M.P.; Menezes A.; Daudt A.W.; Koifman R.; Wunsch-Filho V.; Olshan A.F.; Zevallos J.P.; Sturgis E.M.; Li G.; Levi F.; Zhang Z.-F.; Morgenstern H.; Smith E.; Lazarus P.; La Vecchia C.; Garavello W.; Chen C.; Schwartz S.M.; Zheng T.; Vaughan T.L.; Kelsey K.; McClean M.; Benhamou S.; Hayes R.B.; Purdue M.P.; Gillison M.; Schantz S.; Yu G.-P.; Chuang S.-C.; Boffetta P.; Hashibe M.; Yuan-Chin A.L.; Edefonti V.
File in questo prodotto:
File Dimensione Formato  
32830199.pdf

Accesso aperto con embargo fino al 25/02/2021

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 168.38 kB
Formato Adobe PDF
168.38 kB Adobe PDF Visualizza/Apri
32830199.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 1.2 MB
Formato Adobe PDF
1.2 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1755379
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 19
social impact