There are currently few data concerning the cerebrospinal fluid (CSF) penetration of daptomycin in patients with healthcare-associated meningitis. This study aims (1) to better characterize the pharmacokinetics of daptomycin in humans during a 7-day intravenous (IV) therapy course, and (2) to study the penetration of daptomycin in the CSF after IV infusion at the dose of 10 mg/kg.

Daptomycin Plasma and CSF Levels in Patients with Healthcare-Associated Meningitis

De Nicolò, Amedeo;D'Avolio, Antonio
Last
2019

Abstract

There are currently few data concerning the cerebrospinal fluid (CSF) penetration of daptomycin in patients with healthcare-associated meningitis. This study aims (1) to better characterize the pharmacokinetics of daptomycin in humans during a 7-day intravenous (IV) therapy course, and (2) to study the penetration of daptomycin in the CSF after IV infusion at the dose of 10 mg/kg.
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Daptomycin; Healthcare-associated meningitis; Meningitis; Pharmacokinetics; Ventriculitis
Piva, S; Di Paolo, Antonello; Galeotti, Laura; Ceccherini, Francesco; Cordoni, Francesco; Signorini, Liana; Togni, Tommaso; De Nicolò, Amedeo; Rasulo, Frank A; Fagoni, Nazzareno; Latronico, N; D'Avolio, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1759598
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