Although therapeutic drug monitoring of antiepileptic drugs (AEDs) is typically based on analysis of plasma samples, alternative matrices such as dried plasma spots (DPSs) may offer specific advantages. The aims of this work were to: i) develop and validate a bioanalytical method for the quantitative determination of the second-generation AED perampanel in DPSs; ii) assess short- and long-term stability of perampanel in DPSs; and iii) test the clinical applicability of the developed method.
Determination of Perampanel in Dried Plasma Spots: Applicability to Therapeutic Drug Monitoring
D'Avolio, AntonioCo-last
;
2019-01-01
Abstract
Although therapeutic drug monitoring of antiepileptic drugs (AEDs) is typically based on analysis of plasma samples, alternative matrices such as dried plasma spots (DPSs) may offer specific advantages. The aims of this work were to: i) develop and validate a bioanalytical method for the quantitative determination of the second-generation AED perampanel in DPSs; ii) assess short- and long-term stability of perampanel in DPSs; and iii) test the clinical applicability of the developed method.
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