The broad-spectrum triazole antifungal agent, voriconazole, is widely used in the treatment of invasive fungal infections. Its treatment efficacy and the occurrence of adverse events are associated with plasma drug concentration, rendering inconsistent or inadequate dosing in many patients. The aim of this study was to evaluate the effect of gender, age, body mass index, ethnicity, serum creatinine and drug dose on voriconazole trough concentration.

Effect of Gender and Age on Voriconazole Trough Concentrations in Italian Adult Patients

Allegra, Sarah
First
;
De Francia, Silvia;De Nicolò, Amedeo;Cusato, Jessica;Avataneo, Valeria;Manca, Alessandra;Antonucci, Miriam;D'Avolio, Antonio
Last
2020

Abstract

The broad-spectrum triazole antifungal agent, voriconazole, is widely used in the treatment of invasive fungal infections. Its treatment efficacy and the occurrence of adverse events are associated with plasma drug concentration, rendering inconsistent or inadequate dosing in many patients. The aim of this study was to evaluate the effect of gender, age, body mass index, ethnicity, serum creatinine and drug dose on voriconazole trough concentration.
45
3
405
412
Allegra, Sarah; De Francia, Silvia; De Nicolò, Amedeo; Cusato, Jessica; Avataneo, Valeria; Manca, Alessandra; Antonucci, Miriam; D'Avolio, Antonio
File in questo prodotto:
File Dimensione Formato  
Allegra2020_Article_EffectOfGenderAndAgeOnVoricona.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 930.02 kB
Formato Adobe PDF
930.02 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1759604
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact