The broad-spectrum triazole antifungal agent, voriconazole, is widely used in the treatment of invasive fungal infections. Its treatment efficacy and the occurrence of adverse events are associated with plasma drug concentration, rendering inconsistent or inadequate dosing in many patients. The aim of this study was to evaluate the effect of gender, age, body mass index, ethnicity, serum creatinine and drug dose on voriconazole trough concentration.
Effect of Gender and Age on Voriconazole Trough Concentrations in Italian Adult Patients
Allegra, SarahFirst
;De Francia, Silvia;De Nicolò, Amedeo;Cusato, Jessica;Avataneo, Valeria;Manca, Alessandra;Antonucci, Miriam;D'Avolio, Antonio
Last
2020-01-01
Abstract
The broad-spectrum triazole antifungal agent, voriconazole, is widely used in the treatment of invasive fungal infections. Its treatment efficacy and the occurrence of adverse events are associated with plasma drug concentration, rendering inconsistent or inadequate dosing in many patients. The aim of this study was to evaluate the effect of gender, age, body mass index, ethnicity, serum creatinine and drug dose on voriconazole trough concentration.
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