Sarcomas are a heterogeneous group of relatively rare neoplasms. The only established risk factors of soft tissue sarcomas, which represent 80% of all sarcomas, are ionizing radiation and alkylating agents used in chemotherapy. Extensive research on a possible etiologic role of dioxin, chlorophenoxy herbicides, and chlorophenols has not provided definite evidence of a causal association. A part from an effect of high-level exposure to ionizing radiation detected in historical studies of radiologists and radium-exposed workers, no occupational risk factors have been identified for bone sarcoma.
Soft tissue and bone sarcomas
Garzaro G.;Pira E.;Boffetta P.Last
2020-01-01
Abstract
Sarcomas are a heterogeneous group of relatively rare neoplasms. The only established risk factors of soft tissue sarcomas, which represent 80% of all sarcomas, are ionizing radiation and alkylating agents used in chemotherapy. Extensive research on a possible etiologic role of dioxin, chlorophenoxy herbicides, and chlorophenols has not provided definite evidence of a causal association. A part from an effect of high-level exposure to ionizing radiation detected in historical studies of radiologists and radium-exposed workers, no occupational risk factors have been identified for bone sarcoma.
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