In endothelial cells, trafficking of active α5β1 integrins and polarized fibronectin secretion are important for vascular morphogenesis. A new study unveils how the endothelial small GTPase RHOJ, by repressing trafficking of active α5β1 integrins, controls fibronectin polymerization and in vivo angiogenesis.

Angiogenesis: The Importance of RHOJ-Mediated Trafficking of Active Integrins

Valdembri D.
;
Serini G.
2020-01-01

Abstract

In endothelial cells, trafficking of active α5β1 integrins and polarized fibronectin secretion are important for vascular morphogenesis. A new study unveils how the endothelial small GTPase RHOJ, by repressing trafficking of active α5β1 integrins, controls fibronectin polymerization and in vivo angiogenesis.
2020
30
11
R652
R654
https://linkinghub.elsevier.com/retrieve/pii/S0960-9822(20)30484-X
Valdembri D.; Serini G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1764763
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