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EnglishThe growth factors BDNF and GDNF are gaining more and more attention as modulators of synaptic transmission in the mature central nervous system (CNS). The two molecules undergo a regulated secretion in neurons and may be anterogradely transported to terminals where they can positively or negatively modulate fast synaptic transmission. There is today wide consensus on the role of BDNF as a pro-nociceptive modulator, as the neurotrophin has an important part in the initiation and maintenance of inflammatory, chronic, and/or neuropathic pain at peripheral and central level. At spinal level, BDNF intervenes in the regulation of chloride equilibrium potential, decreases the excitatory synaptic drive to inhibitory neurons, with complex changes in GABAergic/glycinergic synaptic transmission, and increases excitatory transmission in the superficial dorsal horn. Differently from BDNF, the role of GDNF still remains to be unraveled in full. This review resumes the current literature on the interplay between BDNF and GDNF in the regulation of nociceptive neurotransmission in the superficial dorsal horn of the spinal cord. We will first discuss the circuitries involved in such a regulation, as well as the reciprocal interactions between the two factors in nociceptive pathways. The development of small molecules specifically targeting BDNF, GDNF and/or downstream effectors is opening new perspectives for investigating these neurotrophic factors as modulations of nociceptive transmission and chronic pain. Therefore, we finally will consider the molecules of (potential) pharmacological relevance for tackling normal and pathological pain.
| Titolo: | Interplay of BDNF and GDNF in the mature spinal somatosensory system and its potential therapeutic relevance | |
| Autori Riconosciuti: | ||
| Autori: | Ferrini, Francesco; Salio, Chiara; Boggio, Elena; Merighi, Adalberto | |
| Data di pubblicazione: | 2021 | |
| Abstract: | The growth factors BDNF and GDNF are gaining more and more attention as modulators of synaptic transmission in the mature central nervous system (CNS). The two molecules undergo a regulated secretion in neurons and may be anterogradely transported to terminals where they can positively or negatively modulate fast synaptic transmission. There is today wide consensus on the role of BDNF as a pro-nociceptive modulator, as the neurotrophin has an important part in the initiation and maintenance of inflammatory, chronic, and/or neuropathic pain at peripheral and central level. At spinal level, BDNF intervenes in the regulation of chloride equilibrium potential, decreases the excitatory synaptic drive to inhibitory neurons, with complex changes in GABAergic/glycinergic synaptic transmission, and increases excitatory transmission in the superficial dorsal horn. Differently from BDNF, the role of GDNF still remains to be unraveled in full. This review resumes the current literature on the interplay between BDNF and GDNF in the regulation of nociceptive neurotransmission in the superficial dorsal horn of the spinal cord. We will first discuss the circuitries involved in such a regulation, as well as the reciprocal interactions between the two factors in nociceptive pathways. The development of small molecules specifically targeting BDNF, GDNF and/or downstream effectors is opening new perspectives for investigating these neurotrophic factors as modulations of nociceptive transmission and chronic pain. Therefore, we finally will consider the molecules of (potential) pharmacological relevance for tackling normal and pathological pain. | |
| Volume: | 19 | |
| Fascicolo: | 8 | |
| Pagina iniziale: | 1225 | |
| Pagina finale: | 1245 | |
| Digital Object Identifier (DOI): | 10.2174/1570159X18666201116143422 | |
| URL: | https://www.eurekaselect.com/188016/article | |
| Parole Chiave: | BDNF; GDNF; chronic pain; neuropathic pain.; nociception; spinal dorsal horn | |
| Rivista: | CURRENT NEUROPHARMACOLOGY | |
| Appare nelle tipologie: | 03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| CN_post-print_merged.pdf | Postprint_Ferrini et al. 2021 | POSTPRINT (VERSIONE FINALE DELL’AUTORE) | Open Access Visualizza/Apri |
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