Controlled-release transdermal apomorphine treatment for motor fluctuations in Parkinson's disease.

Priano, Lorenzo; Albani, G; Calderoni, S; Baudo, S; Lopiano, Leonardo; Rizzone, M; Astolfi, V; Cavalli, Roberta; Gasco, Mr; Fraschini, F; Bergamasco, Bruno; Mauro, Alessandro

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This study evaluated the efficacy in Parkinson's disease (PD) of a new pharmacologic preparation of apomorphine included in microemulsions and administered by transdermal route, which provides a constant release of the drug for several hours (Apo-TD). Twenty-one PD patients with motor fluctuations were treated with L-dopa alone, with L-dopa plus oral dopamine-agonists, or with L-dopa plus Apo-TD. Apo-TD improved UPDRS-III and tapping test scores in "off" conditions, and reduced duration of "off" periods; no improvement in "on" conditions occurred. We conclude that Apo-TD shows its efficacy particularly by reducing "off" period duration and disability rather than improving motor performances in "on" conditions and therefore it seems a promising treatment for uncontrolled "off" phases in PD patients.

Titolo:	Controlled-release transdermal apomorphine treatment for motor fluctuations in Parkinson's disease.
Autori Riconosciuti:	PRIANO, LORENZO RIZZONE, Mario Giorgio CALDERONI S BAUDO S LOPIANO, Leonardo RIZZONE M ASTOLFI V CAVALLI, Roberta GASCO MR FRASCHINI F BERGAMASCO, Bruno MAURO, Alessandro mostra contributor esterni nascondi contributor esterni
Autori:	PRIANO L; ALBANI G; CALDERONI S; BAUDO S; L. LOPIANO; RIZZONE M; ASTOLFI V; CAVALLI R; GASCO MR; FRASCHINI F; BERGAMASCO B; MAURO A
Data di pubblicazione:	2002
Abstract:	This study evaluated the efficacy in Parkinson's disease (PD) of a new pharmacologic preparation of apomorphine included in microemulsions and administered by transdermal route, which provides a constant release of the drug for several hours (Apo-TD). Twenty-one PD patients with motor fluctuations were treated with L-dopa alone, with L-dopa plus oral dopamine-agonists, or with L-dopa plus Apo-TD. Apo-TD improved UPDRS-III and tapping test scores in "off" conditions, and reduced duration of "off" periods; no improvement in "on" conditions occurred. We conclude that Apo-TD shows its efficacy particularly by reducing "off" period duration and disability rather than improving motor performances in "on" conditions and therefore it seems a promising treatment for uncontrolled "off" phases in PD patients.
Volume:	23 suppl 2
Pagina iniziale:	99
Pagina finale:	100
Rivista:	NEUROLOGICAL SCIENCES
Appare nelle tipologie:	03A-Articolo su Rivista

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Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/2318/1767

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