This study evaluated the efficacy in Parkinson's disease (PD) of a new pharmacologic preparation of apomorphine included in microemulsions and administered by transdermal route, which provides a constant release of the drug for several hours (Apo-TD). Twenty-one PD patients with motor fluctuations were treated with L-dopa alone, with L-dopa plus oral dopamine-agonists, or with L-dopa plus Apo-TD. Apo-TD improved UPDRS-III and tapping test scores in "off" conditions, and reduced duration of "off" periods; no improvement in "on" conditions occurred. We conclude that Apo-TD shows its efficacy particularly by reducing "off" period duration and disability rather than improving motor performances in "on" conditions and therefore it seems a promising treatment for uncontrolled "off" phases in PD patients.

Controlled-release transdermal apomorphine treatment for motor fluctuations in Parkinson's disease.

PRIANO, LORENZO;ALBANI G;LOPIANO, Leonardo;CAVALLI, Roberta;BERGAMASCO, Bruno;MAURO, Alessandro
2002

Abstract

This study evaluated the efficacy in Parkinson's disease (PD) of a new pharmacologic preparation of apomorphine included in microemulsions and administered by transdermal route, which provides a constant release of the drug for several hours (Apo-TD). Twenty-one PD patients with motor fluctuations were treated with L-dopa alone, with L-dopa plus oral dopamine-agonists, or with L-dopa plus Apo-TD. Apo-TD improved UPDRS-III and tapping test scores in "off" conditions, and reduced duration of "off" periods; no improvement in "on" conditions occurred. We conclude that Apo-TD shows its efficacy particularly by reducing "off" period duration and disability rather than improving motor performances in "on" conditions and therefore it seems a promising treatment for uncontrolled "off" phases in PD patients.
23 suppl 2
99
100
PRIANO L; ALBANI G; CALDERONI S; BAUDO S; L. LOPIANO; RIZZONE M; ASTOLFI V; CAVALLI R; GASCO MR; FRASCHINI F; BERGAMASCO B; MAURO A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1767
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