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EnglishThis study evaluated the efficacy in Parkinson's disease (PD) of a new pharmacologic preparation of apomorphine included in microemulsions and administered by transdermal route, which provides a constant release of the drug for several hours (Apo-TD). Twenty-one PD patients with motor fluctuations were treated with L-dopa alone, with L-dopa plus oral dopamine-agonists, or with L-dopa plus Apo-TD. Apo-TD improved UPDRS-III and tapping test scores in "off" conditions, and reduced duration of "off" periods; no improvement in "on" conditions occurred. We conclude that Apo-TD shows its efficacy particularly by reducing "off" period duration and disability rather than improving motor performances in "on" conditions and therefore it seems a promising treatment for uncontrolled "off" phases in PD patients.
| Titolo: | Controlled-release transdermal apomorphine treatment for motor fluctuations in Parkinson's disease. |
| Autori Riconosciuti: | |
| Autori: | PRIANO L; ALBANI G; CALDERONI S; BAUDO S; L. LOPIANO; RIZZONE M; ASTOLFI V; CAVALLI R; GASCO MR; FRASCHINI F; BERGAMASCO B; MAURO A |
| Data di pubblicazione: | 2002 |
| Abstract: | This study evaluated the efficacy in Parkinson's disease (PD) of a new pharmacologic preparation of apomorphine included in microemulsions and administered by transdermal route, which provides a constant release of the drug for several hours (Apo-TD). Twenty-one PD patients with motor fluctuations were treated with L-dopa alone, with L-dopa plus oral dopamine-agonists, or with L-dopa plus Apo-TD. Apo-TD improved UPDRS-III and tapping test scores in "off" conditions, and reduced duration of "off" periods; no improvement in "on" conditions occurred. We conclude that Apo-TD shows its efficacy particularly by reducing "off" period duration and disability rather than improving motor performances in "on" conditions and therefore it seems a promising treatment for uncontrolled "off" phases in PD patients. |
| Volume: | 23 suppl 2 |
| Pagina iniziale: | 99 |
| Pagina finale: | 100 |
| Rivista: | NEUROLOGICAL SCIENCES |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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