Uveal melanoma is a rare disease but it is the most common primary intraocular malignant tumor in adults with poor late prognosis. About 50% of patients will develop liver metastasis far from the enucleation within 10–15 years. Our study examined SPANX-C expression levels in primary uveal melanoma both with and without metastasis to assess if they can be used to predict metastasis. This study included a total of 55 patients, 28 males and 27 females, with uveal melanoma. A significantly high expression of SPANX-C was seen in 19/23 (82.6%) patients with metastasis, and only in 11/32 (38.5%) patients without metastasis. In conclusion, we found that SPANX-C expression could play a role in tumor progression of uveal melanoma.

Immunoexpression of SPANX-C in metastatic uveal melanoma

Reibaldi M.;
2019-01-01

Abstract

Uveal melanoma is a rare disease but it is the most common primary intraocular malignant tumor in adults with poor late prognosis. About 50% of patients will develop liver metastasis far from the enucleation within 10–15 years. Our study examined SPANX-C expression levels in primary uveal melanoma both with and without metastasis to assess if they can be used to predict metastasis. This study included a total of 55 patients, 28 males and 27 females, with uveal melanoma. A significantly high expression of SPANX-C was seen in 19/23 (82.6%) patients with metastasis, and only in 11/32 (38.5%) patients without metastasis. In conclusion, we found that SPANX-C expression could play a role in tumor progression of uveal melanoma.
2019
215
7 (Article number 152431)
152431
152431
http://www.journals.elsevier.com/pathology-research-and-practice/
Immunohistochemistry; Metastasis; SPANX-C; Trailblazer cells; Uveal melanoma
Salvatorelli L.; Puzzo L.; Russo A.; Reibaldi M.; Longo A.; Ragusa M.; Calogero A; Rappazzo G.; Caltabiano R.; Salemi M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1771531
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