Marrow transplantation from a phenotypically identical unrelated donor has become a feasible and curative form of treatment for patients with several malignant and nonmalignant disorders who lack an HLA-matched sibling donor. Given the rapid growth of registries of HLA-typed volunteers (-including over 2 million people-) it is now possible to identify a suitable unrelated marrow donor for up to 50% of patients. In this review the recent acquisitions regarding the structure of HLA complex, the new molecular typing technologies and clinical results obtained with unrelated marrow transplants, will be considered.
Recent advances in bone marrow transplantation from unrelated volunteer donors
Amoroso A.;Miniero R.
1996-01-01
Abstract
Marrow transplantation from a phenotypically identical unrelated donor has become a feasible and curative form of treatment for patients with several malignant and nonmalignant disorders who lack an HLA-matched sibling donor. Given the rapid growth of registries of HLA-typed volunteers (-including over 2 million people-) it is now possible to identify a suitable unrelated marrow donor for up to 50% of patients. In this review the recent acquisitions regarding the structure of HLA complex, the new molecular typing technologies and clinical results obtained with unrelated marrow transplants, will be considered.
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