The role of genetics in IgA nephropathy is still debated: a strong association between the disease and the HLA BW35 antigen was described, but further reports did not support this finding and found poor association with other HLA antigens. Beyond the association with HLA alleles, particularly of class II and III, genes such as DR, DQ and Bf, other polymorphic genes, as C3, seem to be involved in the susceptibility to IgA nephropathy. The role of HLA antigens in the progression of the disease is even more undefined. In the study "Angiotensin Converting enzyme inhibitors (ACE-1) in young patients with IgA nephropathy: effects against deterioration of renal function" the frequency of HLA DRB1 and DQB1 alleles was investigate in 120 IgA nephropathy patients enrolled for the Biomed study, classified in three groups according to severity of disease: 47 young IgA patients, 41 IgA patients with normal and stable renal function and 32 IgA patients on chronic dialysis therapy or who had undergone a kidney transplant. We also compared DRB1 and DQB1 allele frequencies between IgA patients and 109 healthy controls. Some HLA-DQB1 allele was found to be associated with prognosis of IgA nephropathy. Particularly DQB1*05 allele seems to protect from progression of IgA nephropathy to renal failure, while DQB1*03 may be a risk factor. Data on distribution of HLA-DRB1/DQB1 haplotypes are still preliminary, although it seems that some of them may influence IgA nephropathy progression. © 2001 Blackwell Science Ltd.
IgA nephropathy and polymorphism of HLA class II genes
Cravero T.;Curtoni E. S.;Amoroso A.
2001-01-01
Abstract
The role of genetics in IgA nephropathy is still debated: a strong association between the disease and the HLA BW35 antigen was described, but further reports did not support this finding and found poor association with other HLA antigens. Beyond the association with HLA alleles, particularly of class II and III, genes such as DR, DQ and Bf, other polymorphic genes, as C3, seem to be involved in the susceptibility to IgA nephropathy. The role of HLA antigens in the progression of the disease is even more undefined. In the study "Angiotensin Converting enzyme inhibitors (ACE-1) in young patients with IgA nephropathy: effects against deterioration of renal function" the frequency of HLA DRB1 and DQB1 alleles was investigate in 120 IgA nephropathy patients enrolled for the Biomed study, classified in three groups according to severity of disease: 47 young IgA patients, 41 IgA patients with normal and stable renal function and 32 IgA patients on chronic dialysis therapy or who had undergone a kidney transplant. We also compared DRB1 and DQB1 allele frequencies between IgA patients and 109 healthy controls. Some HLA-DQB1 allele was found to be associated with prognosis of IgA nephropathy. Particularly DQB1*05 allele seems to protect from progression of IgA nephropathy to renal failure, while DQB1*03 may be a risk factor. Data on distribution of HLA-DRB1/DQB1 haplotypes are still preliminary, although it seems that some of them may influence IgA nephropathy progression. © 2001 Blackwell Science Ltd.
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