Objectives: We evaluated the risk of lung cancer associated with ever working as a painter, duration of employment and type of painter by histological subtype as well as joint effects with smoking, within the SYNERGY project. Methods: Data were pooled from 16 participating case-control studies conducted internationally. Detailed individual occupational and smoking histories were available for 19 369 lung cancer cases (684 ever employed as painters) and 23 674 age-matched and sex-matched controls (532 painters). Multivariable unconditional logistic regression models were adjusted for age, sex, centre, cigarette pack-years, time-since-smoking cessation and lifetime work in other jobs that entailed exposure to lung carcinogens. Results: Ever having worked as a painter was associated with an increased risk of lung cancer in men (OR 1.30; 95% CI 1.13 to 1.50). The association was strongest for construction and repair painters and the risk was elevated for all histological subtypes, although more evident for small cell and squamous cell lung cancer than for adenocarcinoma and large cell carcinoma. There was evidence of interaction on the additive scale between smoking and employment as a painter (relative excess risk due to interaction >0). Conclusions: Our results by type/industry of painter may aid future identification of causative agents or exposure scenarios to develop evidence-based practices for reducing harmful exposures in painters.

Lung cancer risk in painters: Results from the SYNERGY pooled case-control study consortium

Consonni D.;Merletti F.;Richiardi L.;Boffetta P.;Pearce N.;Forastiere F.;
2021-01-01

Abstract

Objectives: We evaluated the risk of lung cancer associated with ever working as a painter, duration of employment and type of painter by histological subtype as well as joint effects with smoking, within the SYNERGY project. Methods: Data were pooled from 16 participating case-control studies conducted internationally. Detailed individual occupational and smoking histories were available for 19 369 lung cancer cases (684 ever employed as painters) and 23 674 age-matched and sex-matched controls (532 painters). Multivariable unconditional logistic regression models were adjusted for age, sex, centre, cigarette pack-years, time-since-smoking cessation and lifetime work in other jobs that entailed exposure to lung carcinogens. Results: Ever having worked as a painter was associated with an increased risk of lung cancer in men (OR 1.30; 95% CI 1.13 to 1.50). The association was strongest for construction and repair painters and the risk was elevated for all histological subtypes, although more evident for small cell and squamous cell lung cancer than for adenocarcinoma and large cell carcinoma. There was evidence of interaction on the additive scale between smoking and employment as a painter (relative excess risk due to interaction >0). Conclusions: Our results by type/industry of painter may aid future identification of causative agents or exposure scenarios to develop evidence-based practices for reducing harmful exposures in painters.
2021
78
4
269
278
cancer; epidemiology; painters; smoking
Guha N.; Bouaoun L.; Kromhout H.; Vermeulen R.; Bruning T.; Behrens T.; Peters S.; Luzon V.; Siemiatycki J.; Xu M.; Kendzia B.; Guenel P.; Luce D.; Karrasch S.; Wichmann H.-E.; Consonni D.; Landi M.T.; Caporaso N.E.; Gustavsson P.; Plato N.; Merletti F.; Mirabelli D.; Richiardi L.; Jockel K.-H.; Ahrens W.; Pohlabeln H.; Tse L.A.; Yu I.T.-S.; Tardon A.; Boffetta P.; Zaridze D.; Tmannetje A.; Pearce N.; Davies M.P.A.; Lissowska J.; Swiatkowska B.; McLaughlin J.; Demers P.A.; Bencko V.; Foretova L.; Janout V.; Pandics T.; Fabianova E.; Mates D.; Forastiere F.; Bueno-De-Mesquita B.; Schuz J.; Straif K.; Olsson A.
File in questo prodotto:
File Dimensione Formato  
33115922_LR.pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 637.58 kB
Formato Adobe PDF
637.58 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1778365
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 2
social impact