BACKGROUND: It has been speculated that the SARS-CoV-2 was already widespread in western countries before February 2020.METHODS: We gauged this hypothesis by analysing the nasal swab of infants with either bronchiolitis or a non-infectious disease admitted to the Ospedale Maggiore, Milan (one of the first epicentres of SARS-CoV-2 outbreak in Europe) from November 2019.RESULTS: The SARS-CoV-2 RNA was never detected in 218 infants with bronchiolitis (95 females, median age 4.9 months) and 49 infants (22 females, median age 5.6 months) with a non-infectious disease between November 2019 and February 2020. On the contrary, two infants hospitalised for bronchiolitis between March and April 2020 tested positive for SARS-CoV-2.CONCLUSIONS: This study does not support the hypothesis that SARS-CoV-2 was already circulating among infants before the official outbreak of SARS-CoV-2 infection. However, it shows for the first time that SARS-CoV-2 might cause bronchiolitis requiring hospitalisation.

Bronchiolitis and SARS-CoV-2

Luganini, Anna;
2021

Abstract

BACKGROUND: It has been speculated that the SARS-CoV-2 was already widespread in western countries before February 2020.METHODS: We gauged this hypothesis by analysing the nasal swab of infants with either bronchiolitis or a non-infectious disease admitted to the Ospedale Maggiore, Milan (one of the first epicentres of SARS-CoV-2 outbreak in Europe) from November 2019.RESULTS: The SARS-CoV-2 RNA was never detected in 218 infants with bronchiolitis (95 females, median age 4.9 months) and 49 infants (22 females, median age 5.6 months) with a non-infectious disease between November 2019 and February 2020. On the contrary, two infants hospitalised for bronchiolitis between March and April 2020 tested positive for SARS-CoV-2.CONCLUSIONS: This study does not support the hypothesis that SARS-CoV-2 was already circulating among infants before the official outbreak of SARS-CoV-2 infection. However, it shows for the first time that SARS-CoV-2 might cause bronchiolitis requiring hospitalisation.
ARCHIVES OF DISEASE IN CHILDHOOD
1
3
COVID-19; epidemiology; virology
Milani, Gregorio Paolo; Bollati, Valentina; Ruggiero, Luca; Bosis, Samantha; Pinzani, Raffaella Maria; Lunghi, Giovanna; Rota, Federica; Dioni, Laura; Luganini, Anna; Agostoni, Carlo; Marchisio, Paola
File in questo prodotto:
File Dimensione Formato  
Milani et al., 2021.pdf

non disponibili

Tipo di file: PDF EDITORIALE
Dimensione 320.82 kB
Formato Adobe PDF
320.82 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1779993
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 3
  • ???jsp.display-item.citation.isi??? ND
social impact