Goveia et al. use single-cell RNA sequencing to provide an inventory of tumor endothelial cell (TEC) phenotypes from human and mouse non-small cell lung cancer and validate them functionally. Specific TEC phenotypes are associated with prognosis and response to anti-angiogenic therapy.

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Mazzone M.;Wang J.;Li X.;
2020-01-01

Abstract

Goveia et al. use single-cell RNA sequencing to provide an inventory of tumor endothelial cell (TEC) phenotypes from human and mouse non-small cell lung cancer and validate them functionally. Specific TEC phenotypes are associated with prognosis and response to anti-angiogenic therapy.
2020
Inglese
Esperti anonimi
37
1
21
36.e13
15
angiogenesis; anti-angiogenic therapy; cancer; endothelial cells; endothelial heterogeneity; multi-omics; single-cell RNA sequencing; Angiogenesis Inhibitors; Animals; Basement Membrane; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cluster Analysis; Collagen; Endothelial Cells; Endothelium, Vascular; Female; Humans; Lung Neoplasms; Male; Mice; Phenotype; Single-Cell Analysis; Vascular Endothelial Growth Factor A; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Neovascularization, Pathologic
1 – prodotto con file in versione Open Access (allegherò il file al passo 6 - Carica)
262
49
Goveia J.; Rohlenova K.; Taverna F.; Treps L.; Conradi L.-C.; Pircher A.; Geldhof V.; de Rooij L.P.M.H.; Kalucka J.; Sokol L.; Garcia-Caballero M.; Zh...espandi
info:eu-repo/semantics/article
open
03-CONTRIBUTO IN RIVISTA::03A-Articolo su Rivista
File in questo prodotto:
File Dimensione Formato  
Goveia et all, CancerCell, 2020.pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 6.9 MB
Formato Adobe PDF
6.9 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1782148
Citazioni
  • ???jsp.display-item.citation.pmc??? 167
  • Scopus 244
  • ???jsp.display-item.citation.isi??? 251
social impact