Since their discovery, relevant efforts have been made to optimize the detection approaches to EGFR mutations as well as the clinical management of EGFR-mutated NSCLC. The recent shift from single gene testing to novel comprehensive detection platforms along with the development of new generation tyrosine kinase inhibitors, targeting both common and uncommon EGFR-mutations, is leading to a progressive increase in the number of patients who may benefit from targeted approaches, with subsequent impact on their long-term survival and quality of life. However, a prompt and adequate implementation of the most recent diagnostic and treatment advances in the routine practice often remains critical to be specifically addressed. In this review we provide a complete and updated overview of the different detection platforms and therapeutic options currently available for the clinical management of advanced EGFR-positive NSCLC, summarizing scientific evidence and describing molecular testing as well as treatment practice in the real-word scenario.

Dealing with NSCLC EGFR mutation testing and treatment: a comprehensive review with an Italian real-world perspective

Passiglia, Francesco;Righi, Luisella;Bironzo, Paolo;Tabbò, Fabrizio;Reale, Maria Lucia;Novello, Silvia;
2021

Abstract

Since their discovery, relevant efforts have been made to optimize the detection approaches to EGFR mutations as well as the clinical management of EGFR-mutated NSCLC. The recent shift from single gene testing to novel comprehensive detection platforms along with the development of new generation tyrosine kinase inhibitors, targeting both common and uncommon EGFR-mutations, is leading to a progressive increase in the number of patients who may benefit from targeted approaches, with subsequent impact on their long-term survival and quality of life. However, a prompt and adequate implementation of the most recent diagnostic and treatment advances in the routine practice often remains critical to be specifically addressed. In this review we provide a complete and updated overview of the different detection platforms and therapeutic options currently available for the clinical management of advanced EGFR-positive NSCLC, summarizing scientific evidence and describing molecular testing as well as treatment practice in the real-word scenario.
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EGFR; common mutations; molecular testing; non-small cell lung cancer; tyrosine kinase inhibitors; uncommon mutations
Malapelle, Umberto; Pilotto, Sara; Passiglia, Francesco; Pepe, Francesco; Pisapia, Pasquale; Righi, Luisella; Listì, Angela; Bironzo, Paolo; Belluomini, Lorenzo; Tabbò, Fabrizio; Reale, Maria Lucia; Russo, Gianluca; De Luca, Caterina; Novello, Silvia; Troncone, Giancarlo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1782184
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