Bioluminescence detection requires single-photon sensitivity, extremely low detection limits and wide dynamic range. Such performances were traditionally assured by photomultiplier-tubes based systems. However, development of novel applications and industrialization call for the introduction of more robust, compact and scalable devices. Silicon photomultipliers were recently put forward as the alternative to phototubes for a new generation of flexible and user friendly instruments. In this article, the figures of merit of a silicon-photomultiplier based system relying on a compact, low cost system are investigated. Possible implementations are proposed and a proof-of-principle bioluminescence measurement is performed.

Assessment of the potential of SiPM-based systems for bioluminescence detection

Ruffinatti F. A.;
2020

Abstract

Bioluminescence detection requires single-photon sensitivity, extremely low detection limits and wide dynamic range. Such performances were traditionally assured by photomultiplier-tubes based systems. However, development of novel applications and industrialization call for the introduction of more robust, compact and scalable devices. Silicon photomultipliers were recently put forward as the alternative to phototubes for a new generation of flexible and user friendly instruments. In this article, the figures of merit of a silicon-photomultiplier based system relying on a compact, low cost system are investigated. Possible implementations are proposed and a proof-of-principle bioluminescence measurement is performed.
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Bioluminescence; Charge integration; Dynamic range; Limit of detection; Single photon counting; SiPM
Lomazzi S.; Caccia M.; Distasi C.; Dionisi M.; Lim D.; Martemiyanov A.; Nardo L.; Ruffinatti F.A.; Santoro R.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1784700
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