We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester-infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in the non-neutralizing antibodies was observed after 16 weeks of gestation. All the newborns of women who developed IgG antibodies showed the presence of the same antibodies in arterial cord blood. Knowledge on the longevity and type of SARS-CoV-2 antibody response may help to guide vaccination strategies in pregnancy.

Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery

Cosma S.;Carosso A. R.;Corcione S.;Cusato J.;Borella F.;Antonucci M.;Marozio L.;Revelli A.;Preti M.;Di Perri G.;Benedetto C.
2021

Abstract

We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester-infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in the non-neutralizing antibodies was observed after 16 weeks of gestation. All the newborns of women who developed IgG antibodies showed the presence of the same antibodies in arterial cord blood. Knowledge on the longevity and type of SARS-CoV-2 antibody response may help to guide vaccination strategies in pregnancy.
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Antibodies; COVID-19 immunology; COVID-19 vaccines; Pregnancy; SARS-CoV-2; Adult; Antibodies, Neutralizing; Antibodies, Viral; COVID-19; Female; Humans; Immunoglobulin G; Longitudinal Studies; Pregnancy; Pregnancy Complications, Infectious; SARS-CoV-2
Cosma S.; Carosso A.R.; Corcione S.; Cusato J.; Borella F.; Antonucci M.; Marozio L.; Revelli A.; Preti M.; Ghisetti V.; Di Perri G.; Benedetto C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1785559
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