Critical illness from SARS-CoV-2 infection (COVID-19) is associated with a high burden of pulmonary embolism (PE) and thromboembolic events despite standard thromboprophylaxis. Available guidance is discordant, ranging from standard care to the use of therapeutic anticoagulation for enhanced thromboprophylaxis (ET). Local ET protocols have been empirically determined and are generally intermediate between standard prophylaxis and full anticoagulation. Concerns have been raised in regard to the potential risk of haemorrhage associated with therapeutic anticoagulation. This report describes the prevalence and safety of ET strategies in European Intensive Care Unit (ICUs) and their association with outcomes during the first wave of the COVID pandemic, with particular focus on haemorrhagic complications and ICU mortality.

Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients during the first wave of the pandemic: observational report from 28 European intensive care units

Brazzi L;Montrucchio, Giorgia;Sales, Gabriele
2021-01-01

Abstract

Critical illness from SARS-CoV-2 infection (COVID-19) is associated with a high burden of pulmonary embolism (PE) and thromboembolic events despite standard thromboprophylaxis. Available guidance is discordant, ranging from standard care to the use of therapeutic anticoagulation for enhanced thromboprophylaxis (ET). Local ET protocols have been empirically determined and are generally intermediate between standard prophylaxis and full anticoagulation. Concerns have been raised in regard to the potential risk of haemorrhage associated with therapeutic anticoagulation. This report describes the prevalence and safety of ET strategies in European Intensive Care Unit (ICUs) and their association with outcomes during the first wave of the COVID pandemic, with particular focus on haemorrhagic complications and ICU mortality.
2021
25
1
155
164
Anticoagulation; COVID-19; Heparin; Intensive care medicine; Prophylaxis; Thrombosis
Lavinio, Andrea; Ercole, Ari; Battaglini, Denise; Magnoni, Sandra; Badenes, Rafael; Taccone, Fabio Silvio; Helbok, Raimund; Thomas, William; Pelosi, Paolo; Robba, Chiara; Brazzi L; Montrucchio, Giorgia; Sales, Gabriele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1787260
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