Podocyte dysfunction and loss are major determinants in the development of proteinuria. FSGS is one of the most common causes of proteinuria, but the mechanisms leading to podocyte injury or conferring protection against FSGS remain poorly understood. The cytosolic protein M-Sec has been involved in the formation of tunneling nanotubes (TNTs), membrane channels that transiently connect cells and allow intercellular organelle transfer. Whether podocytes express M-Sec is unknown and the potential relevance of the M-Sec-TNT system in FSGS has not been explored.

Protective Role of the M-Sec-Tunneling Nanotube System in Podocytes

Barutta, Federica;Bellini, Stefania;Corbetta, Beatrice;Barreca, Antonella;Papotti, Mauro Giulio;Roccatello, Dario;Audrito, Valentina;Deaglio, Silvia;Gambino, Roberto;Bruno, Stefania;Camussi, Giovanni;Martini, Miriam;Hirsch, Emilio;Durazzo, Marilena;Gruden, Gabriella
2021

Abstract

Podocyte dysfunction and loss are major determinants in the development of proteinuria. FSGS is one of the most common causes of proteinuria, but the mechanisms leading to podocyte injury or conferring protection against FSGS remain poorly understood. The cytosolic protein M-Sec has been involved in the formation of tunneling nanotubes (TNTs), membrane channels that transiently connect cells and allow intercellular organelle transfer. Whether podocytes express M-Sec is unknown and the potential relevance of the M-Sec-TNT system in FSGS has not been explored.
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M-Sec; focal segmental glomerulosclerosis; mitochondria; podocytes; tunneling nanotubes
Barutta, Federica; Kimura, Shunsuke; Hase, Koji; Bellini, Stefania; Corbetta, Beatrice; Corbelli, Alessandro; Fiordaliso, Fabio; Barreca, Antonella; Papotti, Mauro Giulio; Ghiggeri, Gian Marco; Salvidio, Gennaro; Roccatello, Dario; Audrito, Valentina; Deaglio, Silvia; Gambino, Roberto; Bruno, Stefania; Camussi, Giovanni; Martini, Miriam; Hirsch, Emilio; Durazzo, Marilena; Ohno, Hiroshi; Gruden, Gabriella
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1788640
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