dNLR at the baseline (B), defined by neutrophils/[leucocytes-neutrophils], correlates with immune-checkpoint inhibitor (ICI) outcomes in advanced non-small-cell lung cancer (aNSCLC). However, dNLR is dynamic under therapy and its longitudinal assessment may provide data predicting efficacy. We sought to examine the impact of dNLR dynamics on ICI efficacy and understand its biological significance.

Predicting immunotherapy outcomes under therapy in patients with advanced NSCLC using dNLR and its early dynamics

Carnio, Simona;Bironzo, Paolo;Tabbò, Fabrizio;Reale, Maria Lucia;Novello, Silvia;Mariniello, AnnaPaola;
2021

Abstract

dNLR at the baseline (B), defined by neutrophils/[leucocytes-neutrophils], correlates with immune-checkpoint inhibitor (ICI) outcomes in advanced non-small-cell lung cancer (aNSCLC). However, dNLR is dynamic under therapy and its longitudinal assessment may provide data predicting efficacy. We sought to examine the impact of dNLR dynamics on ICI efficacy and understand its biological significance.
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Biomarker; Immunotherapy; NSCLC; Neutrophils; dNLR
Mezquita, Laura; Preeshagul, Isabel; Auclin, Edouard; Saravia, Diana; Hendriks, Lizza; Rizvi, Hira; Park, Wungki; Nadal, Ernest; Martin-Romano, Patricia; Ruffinelli, Jose C; Ponce, Santiago; Audigier-Valette, Clarisse; Carnio, Simona; Blanc-Durand, Felix; Bironzo, Paolo; Tabbò, Fabrizio; Reale, Maria Lucia; Novello, Silvia; Hellmann, Matthew D; Sawan, Peter; Girshman, Jeffrey; Plodkowski, Andrew J; Zalcman, Gerard; Majem, Margarita; Charrier, Melinda; Naigeon, Marie; Rossoni, Caroline; Mariniello, AnnaPaola; Paz-Ares, Luis; Dingemans, Anne Marie; Planchard, David; Cozic, Nathalie; Cassard, Lydie; Lopes, Gilberto; Chaput, Nathalie; Arbour, Kathryn; Besse, Benjamin
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1790644
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